Scientists from Shriners Hospital for Children in St. Louis (USA) have developed a new method of injectable gene therapy that helps convert harmful fatty acids into beneficial ones and prevent excess weight gain. The study results were published in the Proceedings of the National Academy of Sciences (PNAS).
A new method of treating obesity not only fulfills the target function of promoting weight loss, but also significantly improves joint health and reduces inflammatory processes in the body. A key role in such therapy is played by a special virus that does not harm the body because it is inactive. The virus is used as a “transporter” to deliver the desired gene into cells, which allows for targeted changes at the molecular level.
One important aspect of this therapy is the ability to convert omega-6 fatty acids into omega-3 fatty acids. Omega-6s, which are found in certain fatty foods and vegetable oils, can trigger inflammation, which in turn increases the risk of developing diseases such as arthritis, heart disease and metabolic disorders. On the contrary, omega-3s, which are rich in fish and nuts, have an anti-inflammatory effect, improve insulin function and support proper metabolism.
The new treatment reduces the number of cells that cause inflammation, which is especially important for preventing obesity-related arthritis.
Testing on rodents has shown that one injection of gene therapy can effectively counteract the negative effects of fatty foods rich in Omega-6 on joints and metabolism. Scientists have highlighted its effectiveness in combating post-traumatic arthritis, which often occurs in children after knee injuries, such as a torn meniscus.
